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Synthesis 1992; 1992(5): 482-486
DOI: 10.1055/s-1992-26142
DOI: 10.1055/s-1992-26142
paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.
Stereoselective Syntheses of the Antibiotics (+)-Negamycin and (-)-HON (RI-331)
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Publikationsverlauf
Publikationsdatum:
17. September 2002 (online)
![](https://www.thieme-connect.de/media/synthesis/199205/lookinside/thumbnails/10.1055-s-1992-26142-1.jpg)
The stereoselective syntheses of the antibiotics (-)-HON (5-hydroxy-4-oxo-L-norvaline, RI-331) and (+)-negamycin starting from (S)-4-[(Z)-2-(benzyloxycarbonylamino)-2-(tert-butoxycarbonyl)vinyl]-2, 2-dimethyl-1,3-dioxolane and (R)-3-benzyloxycarbonyl-5-[(Z)-2-(tert-butoxycarbonylamino)-2-(methoxycarbonyl) vinyl] -2, 2-dimethyl-1,3-oxazolidine, respectively, are described.