Download PDF
Synthesis 1992; 1992(6): 523-525
DOI: 10.1055/s-1992-26151
short paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Synthesis of 21-Aryl and Heteroaryl Ethisterones and the Corresponding A-Ring Substituted [2,3-d]lsoxazoles

Virendra Kumar* , Alicia B. Todaro
  • *Sterling Research Group, Rensselaer, New York 12144, USA
Further Information

Publication History

Publication Date:
17 September 2002 (online)

  PDF Download  Permissions and Reprints All articles of this category

Palladium(0) catalyzed coupling reaction of ethisterone [6; (17α)-17-hydroxypregn-4-en-20-yn-3-one] with aromatic/heteroaromatic halides gave C-21 substituted derivatives 7. Hydroxymethylation of the latter compounds followed by treatment with hydroxylamine hydrochloride resulted in the formation of 21-substituted (17α)-pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ols 3.