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Synthesis 1992; 1992(6): 523-525
DOI: 10.1055/s-1992-26151
short paper
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Synthesis of 21-Aryl and Heteroaryl Ethisterones and the Corresponding A-Ring Substituted [2,3-d]lsoxazoles

Virendra Kumar* , Alicia B. Todaro
  • *Sterling Research Group, Rensselaer, New York 12144, USA
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Publikationsdatum:
17. September 2002 (online)

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Palladium(0) catalyzed coupling reaction of ethisterone [6; (17α)-17-hydroxypregn-4-en-20-yn-3-one] with aromatic/heteroaromatic halides gave C-21 substituted derivatives 7. Hydroxymethylation of the latter compounds followed by treatment with hydroxylamine hydrochloride resulted in the formation of 21-substituted (17α)-pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ols 3.