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Synthesis 1992; 1992(6): 531-532
DOI: 10.1055/s-1992-26154
short paper
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Studies on Organophosphorus Compounds 55. A New and Facile Synthetic Route to 1-Alkyl(Aryl)-2-amino-1-hydroxyalkylphosphonic Acids

Chengye Yuan* , Deliang Chen
  • *Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, People's Republic of China
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Publikationsdatum:
17. September 2002 (online)

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Nucleophilic addition of dimethyl phosphite to acylamino ketones prepared conveniently by the Dakin-West reaction involving reaction of the corresponding α-amino acids and acid anhydrides, followed by subsequent hydrolysis affords 1-alkyl(aryl)-2-amino-1-hydroxyalkylphosphonic acids in satisfactory yield.