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Synthesis 1992; 1992(6): 533-535
DOI: 10.1055/s-1992-26155
short paper
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A Facile and Convenient Synthetic Method for N-β-Trifluoroacetylvinyl Amino Acid Esters, α-Aminoacetophenones and Aminoacetonitriles as Potentially Useful Precursors of Fluorine-Containing Pyrroles

Etsuji Okada* , Ryoichi Masuda, Masaru Hojo, Ryohei Inoue
  • *Department of Industrial Chemistry, Faculty of Engineering, Kobe University, Kobe 657, Japan
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Publication Date:
17 September 2002 (online)

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N-(4,4,4-Trifluoro-3-oxo-1-butenyl) amino acid esters, α-aminoacetophenones and aminoacetonitriles 3 and 4 are easily obtained in excellent yields by O-N exchange reaction of 4-alkoxy-1,1,1-trifluoro-3-alken-2-ones 1 and 2 with some amino acid esters, α-aminoacetophenone and aminoacetonitrile. Cyclodehydration of some resultant products into fluorine-containing pyrroles is also described.