PDF herunterladen
Synthesis 1992; 1992(6): 533-535
DOI: 10.1055/s-1992-26155
short paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

A Facile and Convenient Synthetic Method for N-β-Trifluoroacetylvinyl Amino Acid Esters, α-Aminoacetophenones and Aminoacetonitriles as Potentially Useful Precursors of Fluorine-Containing Pyrroles

Etsuji Okada* , Ryoichi Masuda, Masaru Hojo, Ryohei Inoue
  • *Department of Industrial Chemistry, Faculty of Engineering, Kobe University, Kobe 657, Japan
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
17. September 2002 (online)

  als PDF herunterladen  Lizenzen und Reprints Alle Artikel dieser Rubrik

N-(4,4,4-Trifluoro-3-oxo-1-butenyl) amino acid esters, α-aminoacetophenones and aminoacetonitriles 3 and 4 are easily obtained in excellent yields by O-N exchange reaction of 4-alkoxy-1,1,1-trifluoro-3-alken-2-ones 1 and 2 with some amino acid esters, α-aminoacetophenone and aminoacetonitrile. Cyclodehydration of some resultant products into fluorine-containing pyrroles is also described.