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Synthesis 1992; 1992(6): 543-544
DOI: 10.1055/s-1992-26159
short paper
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Synthesis of 1,4-Diketones by Reaction of Bicyclic Lactams Derived from 4-Oxoalkanoic Acids with Organolithium Compounds

Christine Wedler* , Hans Schick
  • *Central Institute of Organic Chemistry, Rudower Chaussee 5, D(O)-1199 Berlin-Adlershof, Germany
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Publication Date:
17 September 2002 (online)

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Bicyclic lactams obtained from ethyl 4-oxoalkanoates and 2-aminoethanol add saturated and unsaturated aliphatic lithium compounds forming the corresponding 1,4-diketones in 41-61% yield after acidic hydrolysis.