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Synthesis 1992; 1992(9): 849-851
DOI: 10.1055/s-1992-26245
DOI: 10.1055/s-1992-26245
short paper
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Facile Synthesis of 5-Substituted 2-Acetylthiophenes
Further Information
Publication History
Publication Date:
17 September 2002 (online)
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5-Substituted 2-(α-alkoxyimino)ethylthiophenes 4-8 are obtained by the reaction of 2-(α-alkoxyimino)ethylthiophenes 3 and electrophilic reagents. Hydrolysis of thiophenes 4-8 produces 5-substituted 2-acetylthiophenes 9-13, respectively. Compounds 3 are easily obtained either by the reaction of 2-acetylthiophene (1) and an O-alkylhydroxylamine or by oxidation of 1 followed by O-alkylation.