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Synthesis 1992; 1992(10): 937-939
DOI: 10.1055/s-1992-26268
short paper
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A Novel Synthesis of 3-Substituted Indazole Derivatives

Willard M. Welch* , Catherine E. Hanau, William M. Whalen
  • *Department of Medicinal Chemistry, Central Research Division, Pfizer, Inc., Groton, Connecticut 06340, USA
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Publication Date:
17 September 2002 (online)

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The dianion prepared from 3-bromo-1H-indazole and alkyllithium bases reacts with a variety of electrophiles to give the corresponding 3-monosubstituted 1H-indazole derivatives in moderate yields. This procedure is more general and shorter than earlier methods.