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Synthesis 1992; 1992(10): 972-976
DOI: 10.1055/s-1992-26282
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Chiral Ligands Containing Heteroatoms; 9.1 General Procedures for the Synthesis of Optically Active 1-(2-Pyridyl)alkylamines from α-Amino Acids

Massimo Falorni* , Giorgio Chelucci, Sandra Conti, Giampaolo Giacomelli
  • *Dipartimento di Chimica, Università di Sassari, Via Vienna 2, I-07100 Sassari, Italy
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Publication Date:
17 September 2002 (online)

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General syntheses of 1-(2-pyridyl)alkylamines and N-methyl or N,N-dimethyl-1-(2-pyridyl)alkylamines from optically active α-amino acids are described. The presented procedures are based on catalyzed co-cyclotrimerization of the suitable nitriles with acetylene which can be conducted without loss of optical purity.