Download PDF
Synthesis 1992; 1992(11): 1053-1054
DOI: 10.1055/s-1992-26296
short paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

An Improved Synthesis of 5-Halopyrimidines: Reaction of α-Halo Ketones with Nitriles

A. García Martínez* , A. Herrera Fernández, Dolores Molero Vilchez, M. Hanack, L. R. Subramanian
  • *Departemento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Complutense, E-28040 Madrid, Spain
Further Information

Publication History

Publication Date:
17 September 2002 (online)

  PDF Download  Permissions and Reprints All articles of this category

The reaction of alkyl and aryl α-halomethyl ketones 1 with aliphatic and aromatic nitriles 2 in the presence of trifluoromethanesulfonic anhydride affords substituted 5-halopyrimidines 3 in good yields (55-91%).