Synthesis of Enantiomerically Pure β- and γ-Amino Acids from Aspartic and Glutamic Acid Derivatives

A. El Marini; M. L. Roumestant; Ph. Viallefont; D. Razafindramboa; M. Bonato; M. Follet

doi:10.1055/s-1992-26315

Synthesis 1992; 1992(11): 1104-1108
DOI: 10.1055/s-1992-26315

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Synthesis of Enantiomerically Pure β- and γ-Amino Acids from Aspartic and Glutamic Acid Derivatives

A. El Marini^* , M. L. Roumestant, Ph. Viallefont, D. Razafindramboa, M. Bonato, M. Follet

^*URA 468, Université Montpellier II, Sciences et Techniques du Languedoc, Place E. Bataillon, F-34095 Montpellier Cedex 5, France

Abstract

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An efficient synthesis of enantiomerically pure β- and γ-amino acids starting from commercially available aspartic and glutamic acid derivatives is described. The acid function, α to the amino group, is first transformed to a good leaving group and the product reacted with organocuprates to yield β-and γ-amino esters. After deprotection β- and γ-amino acids are obtained in good overall yields.

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