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Synthesis 1992; 1992(12): 1226-1228
DOI: 10.1055/s-1992-26344
short paper
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A Convenient Synthetic Approach to New α-(9-Fluorenylmethoxycarbonylamino) alkylphosphonic Acid Derivatives

Pascal Dumy* , Roger Escale, Jean Pierre Girard, Joseph Parello, Jean Pierre Vidal
  • *Laboratoire de Chimie des Médiateurs et Physico-Chimie des lntéractions Biologiques associé au C.N.R.S. Université de Montpellier I, Faculté de Pharmacie, 15 avenue Charles Flahaut, F-34060 Montpellier, France
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Publikationsdatum:
29. April 2002 (online)

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Benzyl hydrogen α-(9-fluorenylmethoxycarbonylamino)alkylphosphonates 4, obtained by the sodium metaperiodate oxidation of the corresponding phosphinates 3, were converted to the chloridates 5 and coupled with the N ε-protected lysine benzyl ester to afford peptides 6 containing a phosphonamide bond.