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Synthesis 1992; 1992(12): 1229-1231
DOI: 10.1055/s-1992-26345
DOI: 10.1055/s-1992-26345
short paper
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A Convenient Synthesis of 1-Aryl-2-propanone Precursors of α-Methyldopa
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Publikationsverlauf
Publikationsdatum:
29. April 2002 (online)
![](https://www.thieme-connect.de/media/synthesis/199212/lookinside/thumbnails/10.1055-s-1992-26345-1.jpg)
A simple two-step approach to 1-(3,4-dimethoxyphenyl)- and 1-[3,4-(methylenedioxy)phenyl]-2-propanone (4a and 4b), useful intermediates for α-methyldopa, is described. It is based on the epoxidation of the widely available methyleugenol (1-allyl-3,4-dimethoxybenzene, 1a) and safrole [1-allyI-3,4-(methylenedioxy)benzene, 1b] with hydrogen peroxide catalyzed by tungsten peroxo complex 2a under two-phase conditions, followed by isomerization of the intermediate epoxides 3a and 3b by lithium iodide.