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Synthesis 1992; 1992(12): 1276-1279
DOI: 10.1055/s-1992-26357
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A Facile Synthesis of 2-Phosphoryl-Substituted 3-Hydroxyindole Derivatives

Axel Couture* , Eric Deniau, Pierre Grandclaudon
  • *Laboratoire de Chimie Organique Physique, URA CNRS No 351, Université des Sciences et Technologies de Lille, F-59655 Villeneuve d'Ascq Cédex, France
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Publication Date:
29 April 2002 (online)

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A variety of 1-substituted 2-diphenylphosphinoyl-3-hydroxy-1H-indoles 5a-d and 2-dimethoxyphosphoryl-3-hydroxy-1H-indoles 6a,c have been efficiently prepared by base-induced intramolecular cyclization of the appropriate Horner-Wittig and Wadsworth-Emmons reagents, 2-[(diphenylphosphinoyl)methylamino]-N,N-diethylbenzamides 3a-d and 2-[(dimethoxyphosphoryl)methylamino]-N,N-diethylbenzamides 4a,c, respectively.