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Synthesis 1992; 1992(1/2): 191-195
DOI: 10.1055/s-1992-34158
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Preparation of C-4 Alkylated Dideoxyribosides: Potential Precursors to a Novel Series of Nucleosides

Bruce H. Lipshutz* , Sunaina Sharma, Stuart H. Dimock, James R. Behling
  • *Department of Chemistry, University of California, Santa Barbara, California 93106, USA
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Publication History

Publication Date:
18 September 2002 (online)

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Methallyl alcohol can be converted in five simple operations (alkylation, epoxidation, alkynyl-coupling, hydroboration/oxidation, cyclization) to C-5 protected, chiral, non-racemic dideoxyribosides containing an alkyl appendage at the C-4 site.