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Synthesis 1993; 1993(1): 31-32
DOI: 10.1055/s-1993-25781
short paper
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New Synthesis of Substituted Quinoline N-Oxides via Cyclization of Alkylidene o-Nitroarylacetonitriles

Zbigniew Wròbel* , Andrzej Kwast, Mieczysław Makosza
  • *Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44, PL-01-224 Warsaw, Poland
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Publication Date:
17 September 2002 (online)

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Substituted quinoline N-oxides are prepared via base induced cyclization of alkylidene derivatives of o-nitroarylacetonitriles which are readily available via the vicarious nucleophilic substitution cyanomethylation of nitroarenes followed by the Knoevenagel condensation.