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Synthesis 1993; 1993(1): 45-47
DOI: 10.1055/s-1993-25788
short paper
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Synthesis of α-Amino Isocyanides and α-Alkylthio Isocyanides

Alan R. Katritzky* , Linghong Xie, Wei-Qiang Fan
  • *Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, Florida 32611-2046, USA
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Publication History

Publication Date:
17 September 2002 (online)

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α-Morpholinobenzyl isocyanide and three 1-(aryl[or alkyl]thio)alkyl isocyanides are synthesized in good yields by the dehydration of N-(α-morpholinobenzyl)formamide and N-[1-(alkylthio)alkyl]formamides, themselves prepared from 1-(1-formylaminoalkyl)benzotriazoles with morpholine or with thiols.