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Synthesis 1993; 1993(1): 51-53
DOI: 10.1055/s-1993-25790
DOI: 10.1055/s-1993-25790
short paper
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A General Oxindole Synthesis
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Publikationsverlauf
Publikationsdatum:
17. September 2002 (online)
A general synthesis of indol-2(3H)-ones (oxindoles), was developed based on the addition of dimethyl malonate to commercially available halonitrobenzenes. The advantage of this route over many other oxindole syntheses was the regiochemical control of the substitution pattern on the aromatic ring.