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Synthesis 1993; 1993(1): 121-125
DOI: 10.1055/s-1993-25813
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Reductive N-Monoalkylation of Primary Aromatic Amines

Giancarlo Verardo* , Angelo G. Giumanini, Paolo Strazzolini, Marco Poiana
  • *Department of Chemical Sciences and Technologies, University of Udine, I-33100 Udine, Italy
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Publication History

Publication Date:
17 September 2002 (online)

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Primary aromatic amines 1 with a variety of ring substituents are easily converted to their N-monoalkyl derivatives 3 by a simple variation of the sodium borohydride/sulfuric acid/carbonyl compound procedure previously described for their N-permethylations. The procedure is suitable for the α-monodeuterium labelling of the new N-substituent.