Download PDF
Synthesis 1993; 1993(1): 125-128
DOI: 10.1055/s-1993-25814
paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

General Synthesis and Properties of 1-Monosubstituted Xanthines

Christa E. Müller*
  • *Pharmazeutisches Institut, Pharmazeutische Chemie, Universität Tübingen, Auf der Morgenstelle 8, D-7400 Tübingen, Germany
Further Information

Publication History

Publication Date:
17 September 2002 (online)

  PDF Download  Permissions and Reprints All articles of this category

A general convenient synthesis of 1-monosubstituted xanthines (7H-imidazo[4,5-dlpyrimidine-2,6(1H,3H)-diones), starting from 3-substituted 6-aminouracils, is described. After conversion of the 6-aminouracils to the corresponding 5,6-diaminouracils, reaction with formic acid, or with triethyl orthoformate, leads to the novel xanthines in good to excellent yields, while ring closure in alkaline medium, which is commonly used in xanthine synthesis, is not successful.