Download PDF
Synthesis 1993; 1993(8): 783-785
DOI: 10.1055/s-1993-25940
short paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Studies on Isocyanides and Related Compounds: A Novel Synthetic Route to Furan Derivatives

Ricardo Bossio* , Stefano Marcaccini, Roberto Pepino, Tomás Torroba
  • *CNR, Centro di Studio sulla Chimica e la Struttura dei Composti Eterociclici e loro Applicazioni, Dipartimento di Chimica Organica "Ugo Schiff", Universita' di Firenze, via Gino Capponi 9, I-50121 Firenze, Italy
Further Information

Publication History

Publication Date:
27 September 2002 (online)

  PDF Download  Permissions and Reprints All articles of this category

The Passerini reaction between arylglyoxals 1, isocyanides 2, and cyanoacetic acid affords N-substituted 3-aryl-2-cyanoacetoxy-3-oxopropionamides 3, which are cyclized in the presence of triethylamine to give N-substituted 3-aryl-4-cyano-2,5-dihydro-5-oxofuran-2-carboxamides 4