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Synthesis 1993; 1993(8): 815-818
DOI: 10.1055/s-1993-25948
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The Total Synthesis of Antrimycin Dv; III:1 Construction of the Protected Hexapeptide and Deprotection

Ulrich Schmidt* , Bernd Riedl
  • *Institut für Organische Chemie und Isotopenforschung der Universität Stuttgart, Pfaffenwaldring 55, D-7000 Stuttgart 80, Germany
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Publication Date:
27 September 2002 (online)

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In the preceding communication we described the synthesis of tetrahydropyridazine-3-carboxylic acids and their incorporation into peptides. We have also prepared the tripeptide 2 which is contained in the antibiotic antrimycin Dv 15. We now report on the preparation of the building blocks 1 and 4 and their coupling with 2 to give the protected antrimycin Dv 14. The deprotection of this heptapeptide constitutes the total synthesis of antrimycin Dv.