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Synthesis 1993; 1993(9): 855-857
DOI: 10.1055/s-1993-25954
short paper
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Lipase Catalyzed Enantioselective Hydrolysis of (±)-2-Acetoxy-1-chloro-3-phthalimidopropane

Mirjana Gelo* , Vitomir Šunjić
  • *"Ruder Bošković" Institute, P.O. Box 1016, 41001 Zagreb, Croatia
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Publikationsdatum:
29. April 2002 (online)

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Enzymatic kinetic resolution of (±)-2-acetoxy-1-chloro-3-phthalimidopropane (6) was achieved with Pseudomonas sp. lipase, affording (-)-5 with nearly complete enantioselectivity (ee's 95-99%).