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Synthesis 1993; 1993(9): 858-860
DOI: 10.1055/s-1993-25955
short paper
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Facile Amide Bond Formation From Esters of Amino Acids and Peptides Catalyzed by Alkaline Protease in Anhydrous tert-Butyl Alcohol Using Ammonium Chloride/Triethylamine as a Source of Nucleophilic Ammonia

Shui-Tein Chen* , Ming-Kuei Jang, Kung-Tsung Wang
  • *Laboratory of Biocatalyst, Institute of Biological Chemistry, Academia Sinica, P. O Box 23-106, Taipei, Taiwan, 10098
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Publication Date:
29 April 2002 (online)

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An industrial alkaline protease "Alcalase", stable and active in tert-butyl alcohol, was used to catalyze the synthesis of N-protected amino acids or peptide amides in anhydrous tert-butyl alcohol using ammonium chloride/triethylamine as source of nucleophilic ammonia