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Synthesis 1993; 1993(10): 993-997
DOI: 10.1055/s-1993-25987
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Synthesis of Substituted Quinoline-4-carboxylic Acids

Karen Lackey* , Daniel D. Sternbach
  • *Glaxo Research Institute, Five Moore Drive, Research Triangle Park, North Carolina 27709, USA
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Publication History

Publication Date:
29 April 2002 (online)

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A high yielding synthesis of a variety of quinoline-4-carboxylic acids has been accomplished using a modified Pfitzinger approach involving the condensation of a ketone with an isatin derivative employing aqueous acid conditions. A convenient synthesis of the substituted isatin precursor is also described.