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Synthesis 1993; 1993(12): 1225-1226
DOI: 10.1055/s-1993-26029
short paper
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A New Simple Route to N,O-Protected (S)-2-Amino-4-oxobutyric Acid

Eckehard Volker Dehmlow* , Ralf Westerheide
  • *Fakultät für Chemie, Universität Bielefeld, D-33 615 Bielefeld, Germany
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Publication Date:
29 April 2002 (online)

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Methionine is converted into the N,O-protected derivative 1b. Chlorination of 1b with sulfuryl chloride results in a mixture of the α-halosulfides 2a and 2b in the ratio of 6:1. Hydrolysis of 2a gives the title compound 3 in 64 % yield.