Download PDF
Synthesis 1993; 1993(12): 1221-1222
DOI: 10.1055/s-1993-35864
short paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

An Improved Synthesis of a Mixture of Diethyl (Z)- and (E)-3-Methylglutaconates from Ethyl Acetoacetate

Kaleria I. Kuchkova* , Alla B. Morari, Pavel F. Vlad
  • *Institutul de chimie al Academiei de ŞtiinŢe a Republicii Moldova, strada Academiei 3, 277 028 Chişinau, Moldavia
Further Information

Publication History

Publication Date:
29 April 2002 (online)

  PDF Download  Permissions and Reprints All articles of this category

A simple, efficient two-step synthesis of a mixture of diethyl (Z)- and (E)-3-methylglutaconates from isodehydroacetic acid in 83 % yield is described. On the basis of this synthesis an improved procedure for the preparation of a mixture of (Z)- and (E)-3-methylglutaconic acids from ethyl acetoacetate in 44 % overall yield was elaborated.