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Synlett 1994; 1994(2): 143-144
DOI: 10.1055/s-1994-22771
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Preparation of Optically Active 6-Substituted 2-Piperidones by Oxidation of the Corresponding Oxazolopiperidines.

Philippe Lienard* , Teresa Varea, Jean-Charles Quirion, Henri-Philippe Husson
  • *ICSN-CNRS; 91198 Gif/Yvette Cedex, France.
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Publication Date:
22 March 2002 (online)

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Optically active 6-substituted 2-piperidones 4 and 5 were prepared in good yields (52%-80%) by treatment of corresponding aminoethers 2 and 3 with bromine in CHCl3.