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Synlett 1994; 1994(3): 171-172
DOI: 10.1055/s-1994-22780
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Phase Transfer Mediated Serine O-Alkylation

Michael J. Palmer* , John C. Danilewicz, Hannah Vuong
  • *Pfizer Central Research, Sandwich, Kent, CT13 9NJ, England
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Publication Date:
22 March 2002 (online)

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N-Trityl-L-serine carboxylic esters are smoothly O-alkylated without racemisation under phase transfer conditions. The process is most effective for activated electrophiles and offers significant improvement in terms of convenience, reproducibility and yield over literature procedures.