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Synlett 1994; 1994(4): 289-290
DOI: 10.1055/s-1994-22832
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Facile Enzymatic Synthesis of Optically Active 2,5-Hexanediol Derivatives and Its Application to the Preparation of Optically Pure Cyclic Sulfate for Chiral Ligands

Hazuki Nagai* , Toshiaki Morimoto, Kazuo Achiwa
  • *School of Pharmaceutical Sciences, University of Shizuoka 52-1 Yada, Shizuoka 422, Japan
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Publication Date:
22 March 2002 (online)

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Optically active 2,5-hexanediol derivatives were obtained by lipase-catalyzed esterification with vinyl acetate. Its application to the synthesis of an optically active cyclic sulfate was demonstrated.