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Synlett 1994; 1994(5): 371-372
DOI: 10.1055/s-1994-22858
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Nickel-Catalyzed Cross-Coupling Reaction of Aryl Halides in Pyridine. A Practical Synthesis of 4′-Methylbiphenyl-2-carbonitrile As a Key Intermediate of Angiotensine II Receptor Antagonists

Hiroyuki Kageyama* , Tomonori Miyazaki, Yoshikazu Kimura
  • *Research and Development Department, Ihara Chemical Industry Co., Ltd., Fujikawa-cho, Ihara-gun, Shizuoka 421-33, Japan
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Publication Date:
22 March 2002 (online)

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The title reaction was found to afford unsymmetrical biphenyl derivatives little less than 70% selectivity, which was strongly depended on the aryl halides employed. 4′-Methyl-1,1′-biphenyl-2-carbonitrile was isolated in 59% yield as a pure state by a simple crosscoupling reaction of 4-bromotoluene and 2-chlorobenzonitrile.