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Synlett 1994; 1994(5): 379-380
DOI: 10.1055/s-1994-22862
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Preparation of Enantiomerically Pure Homophenylalanine Derivatives by Palladium-Catalysed Coupling Reactions

Joanne L. Fraser* , Richard F. W. Jackson, Barry Porter
  • *Department of Chemistry, Bedson Building, The University of Newcastle, Newcastle upon Tyne, NE1 7RU, UK
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Publication Date:
22 March 2002 (online)

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Reaction of the glutamic acid derived organozinc reagent 3 with aromatic iodides under palladium catalysis at 50 °C gives homophenylalanine derivatives 5; conversion of adduct 5a to Z-homophenylalanine methyl ester 6 using LiOMe in methanol establishes the usefulness of this method for the preparation of homophenylalanine derivatives.