ω-Aminoalkylheterocycles - Actual Aspects of the Chemistry of Histamine Analogues

J. Liebscher; M. Pätzel

doi:10.1055/s-1994-22894

Synlett 1994; 1994(7): 471-478
DOI: 10.1055/s-1994-22894

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ω-Aminoalkylheterocycles - Actual Aspects of the Chemistry of Histamine Analogues

J. Liebscher^* , M. Pätzel

^*Fachbereich Chemie, Humboldt-Universität Berlin, Hessische Str. 1-2, D-10115 Berlin, Germany

Abstract

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ω-Aminoalkylheterocycles are of broad interest as natural products and biologically active compounds. New syntheses in this class of compounds by asymmetric side chain modification or ring chain transformation reactions are reviewed. The compounds obtained exhibit unusual properties such as unexpected reactions, ring chain tautomerism, pH-dependent formation of different isomers due to the co-operative interactions of both subunits, i. e. alkylamine and heterocycle. 1. Introduction 2. Syntheses 3. Unusual Properties and Reactions

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