Download PDF
Synthesis 1994; 1994(1): 47-50
DOI: 10.1055/s-1994-25403
paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Selective Functionalization of Calix[6]arenes at the Upper Rim

Javier de Mendoza* , Mar Carramolino, Felix Cuevas, Pedro Manuel Nieto, Pilar Prados, David N. Reinhoudt, Willem Verboom, Rocco Ungaro, Alessandro Casnati
  • *Departamento de Química, Universidad Autónoma de Madrid, Cantoblanco, E-28049 Madrid, Spain
Further Information

Publication History

Publication Date:
17 September 2002 (online)

  PDF Download  Permissions and Reprints All articles of this category

Methylation of partially O-benzylated p-tert-butylcalix[6]arenes followed by hydrogenolysis constitutes an efficient method for the preparation of partially O-alkylated Calix[6]arenes in gram amounts, without adhering to column chromatography separations. Selective de-tert-butylation followed by halogenation, or ipso-nitration of these precursors affords Calix[6]arenes containing bromo- or nitrosubstituents, respectively, at precise positions of the upper rim.