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Synthesis 1994; 1994(1): 56-60
DOI: 10.1055/s-1994-25405
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α-Isocyanatoacrylonitriles from Alkylidene- or Arylidenecyanoacetic Acids; Synthesis and Reactions

Ihsan Jaafar* , Georges Francis, Renée Danion-Bougot, Daniel Danion
  • *Groupe de Recherches de Physicochimie Structurale, U.R.A. C.N.R.S. 704, F-35042 Rennes Cédex, France
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Publication History

Publication Date:
17 September 2002 (online)

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The Curtius reaction converts alkylidene- or arylidenecyanoacetic acids to α-isocyanatoacrylonitriles in a stereospecific way. These versatile intermediates allow an easy access to arylacetic acids and various amino acid derivatives, as well as β-lactams or 2-azabutadienes.