Synthesis 1994; 1994(2): 190-194
DOI: 10.1055/s-1994-25436
paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

A Short and Efficient Diastereoselective Synthesis of 2′-Substituted 2- Cyclopropylglycines

Jürgen Zindel* , Armin de Meijere
  • *Institut für Organische Chemie der Georg-August-Universität Göttingen, Tammannstraße 2, D-37077 Göttingen, Germany
Further Information

Publication History

Publication Date:
17 September 2002 (online)

Diastereomerically pure 2-cyclopropylglycines 2, 2′-substituted with an electron-withdrawing group, were prepared in two steps by Michael addition of the glycine equivalent 2-(diphenylmethyleneamino)acetate 11 to various Michael acceptors of type 1 with subsequent γ-elimination of bromide and followed by acid mediated deprotection.