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Synthesis 1994; 1994(2): 190-194
DOI: 10.1055/s-1994-25436
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A Short and Efficient Diastereoselective Synthesis of 2′-Substituted 2- Cyclopropylglycines

Jürgen Zindel* , Armin de Meijere
  • *Institut für Organische Chemie der Georg-August-Universität Göttingen, Tammannstraße 2, D-37077 Göttingen, Germany
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Publication History

Publication Date:
17 September 2002 (online)

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Diastereomerically pure 2-cyclopropylglycines 2, 2′-substituted with an electron-withdrawing group, were prepared in two steps by Michael addition of the glycine equivalent 2-(diphenylmethyleneamino)acetate 11 to various Michael acceptors of type 1 with subsequent γ-elimination of bromide and followed by acid mediated deprotection.