PDF herunterladen
Synthesis 1994; 1994(2): 190-194
DOI: 10.1055/s-1994-25436
paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

A Short and Efficient Diastereoselective Synthesis of 2′-Substituted 2- Cyclopropylglycines

Jürgen Zindel* , Armin de Meijere
  • *Institut für Organische Chemie der Georg-August-Universität Göttingen, Tammannstraße 2, D-37077 Göttingen, Germany
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
17. September 2002 (online)

  als PDF herunterladen  Lizenzen und Reprints Alle Artikel dieser Rubrik

Diastereomerically pure 2-cyclopropylglycines 2, 2′-substituted with an electron-withdrawing group, were prepared in two steps by Michael addition of the glycine equivalent 2-(diphenylmethyleneamino)acetate 11 to various Michael acceptors of type 1 with subsequent γ-elimination of bromide and followed by acid mediated deprotection.