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Synthesis 1994; 1994(2): 199-202
DOI: 10.1055/s-1994-25438
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Nucleophilic Aromatic Substitution Reactions of 1-Methoxy-2-(diphenylphosphinyl)naphthalene with C-, N-, and O-Nucleophiles: Facile Synthesis of Diphenyl(1-substituted-2-naphthyl)phosphines

Tetsutaro Hattori* , Jun'ichi Sakamoto, Noriyuki Hayashizaka, Sotaro Miyano
  • *Department of Biochemistry and Engineering, Faculty of Engineering, Tohoku University, Aramaki-Aoba, Aoba-ku, Sendai 980, Japan
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Publication Date:
17 September 2002 (online)

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A novel nucleophilic aromatic substitution reaction is described in which the methoxy group of 1-methoxy-2-(diphenylphosphinyl)-naphthalene is readily replaced with Grignard reagents, alkoxides, and amides. Reduction of the resulting phosphine oxides provides a convenient route to diphenyl(1-substituted-2-naphthyl)phosphines.