Download PDF
Synthesis 1994; 1994(2): 203-206
DOI: 10.1055/s-1994-25439
paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Syntheses of 6- or 8-Carbon-Substituted 2-Oxopurines

Tatsunori Iwamura* , Yoshinori Okamoto, Masaharu Yokomoto, Hiroshi Shimizu, Mikio Hori, Tadashi Kataoka
  • *Gifu Pharmaceutical University, 6-1, Mitahora-higashi 5-chome Gifu 502, Japan
Further Information

Publication History

Publication Date:
17 September 2002 (online)

  PDF Download  Permissions and Reprints All articles of this category

Reaction of 3,7-dimethyl-6-methylthio-2-oxopurine (1) with Grignard reagents or organolithiums afforded 8-adducts 2, whereas the corresponding reaction of 3,7-dimethyl-2-oxopurine (6) gave 6-adducts 7. The adducts 2 and 7 were converted into 8-substituted theobromines 4 and 6-substituted 3,7-dimethyl-2-oxopurines 8, respectively. 8-Chlorotheobromine (5) reacted with Grignard reagents in the presence of a catalytic amount of NiBr2,(PPh3)2 to give 4 in good yields.