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Synthesis 1994; 1994(3): 309-312
DOI: 10.1055/s-1994-25466
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A Convenient Method for Preparing Some New Macrocyclic Diamides

Lilian Kao Liu* , Tsing-Pai Hsieh, Sung-Ming Kuo
  • *Department of Chemistry, National Taiwan Normal University, Taipei 117, Taiwan, Republic of China
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Publication Date:
27 September 2002 (online)

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A simple and convenient method for preparing macrocyclic diamides containing two sulfur atoms or two to four oxygen atoms of various ring sizes was developed. This two-step procedure is simply composed of reacting salicyclic acid or 2-mercaptobenzoic acid with various diamines, followed by a Williamson synthesis.