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Synthesis 1994; 1994(7): 672-674
DOI: 10.1055/s-1994-25541
short paper
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Synthesis of N,N′-Diaryldipeptide Amides by Multi-Component Condensation Utilizing Potassium Isocyanoacetate

Ricardo Bossio* , Stefano Marcaccini, Paola Paoli, Roberto Pepino
  • *CNR, Centro di Studio sulla Chimica e la Struttura dei Composti Eterociclici e loro Applicazioni, Dipartimento di Chimica Organica "Ugo Schiff", Università di Firenze, via Gino Capponi 9, I-50121 Firenze, Italy
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Publikationsdatum:
17. September 2002 (online)

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The reaction between ketones 1, amine hydrochlorides 2, and potassium isocyanoacetate (3) affords a series of dipeptide derivatives 5. The structure of compounds 5 is in agreement with their spectral data and is confirmed by means of X-ray analysis of 5a.