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Synthesis 1994; 1994(8): 779-781
DOI: 10.1055/s-1994-25571
short paper
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Synthesis of Octacarboxytetra(2,3-pyrazino)porphyrazine: Novel Water Soluble Photosensitizers for Photodynamic Therapy

Svetlana V. Kudrevich* , Maria G. Galpern, Johan E. van Lier
  • *MRC Group in the Radiation Sciences, Faculty of Medicine, University of Sherbrooke, Sherbrooke (Québec) J1H 5N4, Canada
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Publikationsdatum:
17. September 2002 (online)

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The condensation of 2,3-dicyano-5,6-diethoxycarbonylpyrazine with a metal salt affords tetra-2,3-(5,6-diethoxycarbonylpyrazino)porphyrazine, which upon mild hydrolysis yields novel water-soluble metal complexes of tetra-2,3-(5,6-dicarboxypyrazino)porphyrazine. These octaaza analogs of phthalocyanine have potential applications in the field of photodynamic therapy of cancer.