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Synthesis 1994; 1994(8): 800-804
DOI: 10.1055/s-1994-25578
DOI: 10.1055/s-1994-25578
paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.
Convenient Synthesis of Trichloromethyldihydroquinolines and -isoquinolines
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Publikationsverlauf
Publikationsdatum:
17. September 2002 (online)
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The reaction of a series of N-alkylquinolinium and -isoquinolinium iodides towards sodium trichloroacetate in acetonitrile has been investigated under reflux or ultrasonication. In all cases, addition of trichloromethyl anion was observed, and trichloromethyldihydroquinoline or -isoquinoline derivatives were obtained in good yields. Depending on the activation process, addition occured at the 2- or the 4-position with quinolines and at the 1-position with isoquinolines.