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Synthesis 1994; 1994(11): 1127-1128
DOI: 10.1055/s-1994-25651
short paper
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Hofmann Rearrangement of Primary, Substituted Acetamides to Nitriles with a Hypochlorite Liquid Triphasic System

John Correia*
  • *Department of Chemistry, Saint Mary's College, P.O. Box 4527, Moraga, California 94575, USA
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Publikationsdatum:
25. April 2002 (online)

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A hypochlorite liquid triphasic system prepared from aqueous sodium hypochlorite, sodium bromide, and tetrabutylammonium hydrogen sulfate was found to be effective in converting primary, substituted acetamides to nitriles with loss of one carbon via the Hofmann rearrangement in yields of 48-68 %.