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Synthesis 1994; 1994(12): 1257-1261
DOI: 10.1055/s-1994-25676
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Synthese der natürlichen R-( - )Enantiomere dreier Galbanum-Harz Macrolide

Hans Jürgen Bestmann* , Wilfried Kellermann
  • *Institut für Organische Chemie der Universität Erlangen-Nürnberg, Henkestr. 42, D-91054 Erlangen, Germany
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Publikationsdatum:
25. April 2002 (online)

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The three macrolides 1, 2 and 3 isolated from galbanum resin were synthesized starting from ω-bromoacetals 9. The key step is the buffered intramolecular Wittig reaction of the ylides 14 and 23 to afford the α,β-unsaturated lactones 15, 16 and 24. Hydrogenation of these lactones gives the title macrolides in (R)-configuration.