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Synthesis 1994; 1994(12): 1278-1282
DOI: 10.1055/s-1994-25681
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A Second Generation Photochemically Activatable Dynemicin Analog: A Concise Synthesis and DNA Cleavage Studies

Paul A. Wender* , Suzanne Beckham, Jacqueline G. O'Leary
  • *Department of Chemistry, Stanford University, Stanford, CA 94305, USA
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Publication Date:
25 April 2002 (online)

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A scheme for the design of dynemicin analogs and a concise, efficient route for their synthesis are described. A photochemically activatable analog was prepared and shown to undergo cycloaromatization upon irradiation with wavelengths greater than 300 nm. The ability of this compound to function as a competent DNA cleaving agent is demonstrated.