RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000084.xml
Synthesis 1994; 1994(12): 1331-1336
DOI: 10.1055/s-1994-25690
DOI: 10.1055/s-1994-25690
paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.
Efficient Synthesis of Enantiopure Tretrahydroisoquinolines by Diastereoselective Intramolecular Heck Reaction Using α-Amino Acid Derivatives
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
25. April 2002 (online)
![](https://www.thieme-connect.de/media/synthesis/199412/lookinside/thumbnails/10.1055-s-1994-25690-1.jpg)
A new facile method for the synthesis of enantiopure 3,4-disubstituted tetrahydroisoquinolines 10a-d and 14 is described. Starting from commercially available α-amino acids the compounds 3a-d and 4 were prepared by an easy five-step sequence and afterwards cyclized selectively in an intramolecular Heck reaction using Pd(OAc)2, PPh3, TPAB and KOAc.