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Synthesis 1994; 1994(12): 1401-1402
DOI: 10.1055/s-1994-25699
short paper
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A Facile Synthesis of 2-(Aminomethyl)purines

Michal Hocek* , Milena Masojídková, Antonín Holý
  • *Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, CZ-16610 Prague 6, The Czech Republic
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Publikationsdatum:
25. April 2002 (online)

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A simple synthesis of 2-(aminomethyl)purines is reported. Imidate intermediates are formed by condensation of the Cb-glycine orthoester with 4-aminoimidazole-5-carboxylic acid derivatives, and are further cyclized to 2-(Cb-aminomethyl)purines.