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Synthesis 1994; 1994(12): 1429-1432
DOI: 10.1055/s-1994-25707
DOI: 10.1055/s-1994-25707
paper
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Chiral Ligands Containing Heteroatoms; 12.1 Synthesis of Optically Active 2-Amino-2-(2′-pyridyl)-1-alkanols from β-Hydroxy-α-amino Acids
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Publikationsdatum:
25. April 2002 (online)
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The synthesis of a new class of optically active ligands such as the title compounds is presented. All the multistep procedures adopted start by the conversion of L-serine and L-threonine into the proper 2,2-dimethyloxazolidines, followed by transformation of the corresponding nitriles to pyridines. The reaction sequence occurs without loss of enantiomeric purity and with overall satisfactory yield.